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Home > Pharmaceutical

Pharmaceutical

ultrasonic processing for pharmaceutical applications - nanoemulsions, liposomes, nanocrystallization
  • Manufacture uniform nanocrystals, nanoemulsions, and liposomes on laboratory, bench and industrial scales.
  • Greatly increase the bioavailability and accelerate the onset of action of hydrophobic bioactive compounds.
  • Extract active pharmaceutical ingredients from biomass by efficient cell disruption (lysis).

Overview

Up to 40% of currently available bioactive substances and up to 70% of those under investigation by the pharmaceutical industry exhibit poor water solubility, resulting in low bioavailability and a delayed onset of action. Drug delivery platforms based on nanocarriers, such as nanocrystals, nanoemulsions, and liposomes, are very effective at overcoming these limitations. Industrial Sonomechanics® laboratory, bench, and industrial ultrasonic liquid processors provide a simple and effective means of producing uniform nanoparticles by exposing materials to high-intensity ultrasonic cavitation and the extremely strong shear forces it generates. These forces are also essential to the process of cell disruption (lysis), which is an important step in the extraction of pharmaceutical agents (e.g., recombinant proteins, medicinal oils, other bioactive substances) from yeast, bacterial and plant cells.

With Industrial Sonomechanics® patented Barbell Horn® Ultrasonic Technology (BHUT), these processes can be easily implemented at any scale of operation, guaranteeing reproducible and predictable high-quality results.
stock-photo-scientist-with-dropper-working-at-the-laboratory-127847810

Case Studies & Application Reports

Ultrasonic Disruption of Yeast Cells
CASE STUDY
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Scaling Up the Production of a Nanoemulsion with BHUT
CASE STUDY
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Ultrasonic Nanocrystallization of Nifedipine
CASE STUDY
Download PDF Ultrasonic nanocrystallization of nifedipine
Drug Carrier Liposomes and Nanoemulsions
APPLICATION REPORT
Download PDF
View all case studies

Blog Posts

How Stable Are Nanoemulsions Made with NanoStabilizer®-LT and NanoStabilizer®-LSO? Here's the Data.
04/14/25

How Stable Are Nanoemulsions Made with NanoStabilizer®-LT and NanoStabilizer®-LSO? Here's the Data.

One of the most common questions we receive from customers is about the long-term stabil... Read more...
Using a High-Pressure Homogenizer? Produce Superior Nanoemulsions with All-In-One NanoStabilizers®
02/12/25

Using a High-Pressure Homogenizer? Produce Superior Nanoemulsions with All-In-One NanoStabilizers®

All-In-One NanoStabilizers® have transformed the cannabis and nutraceutical industries b... Read more...
Highly Concentrated Nanoemulsions With Sub-100 nm Droplets: Here’s How to Make Them
02/03/25

Highly Concentrated Nanoemulsions With Sub-100 nm Droplets: Here’s How to Make Them

Producing fast-acting, highly bioavailable, readily water-soluble nanoemulsions of bioac... Read more...
Read all Blog Posts

Customer Testimonials

Dominic Notter, Matrix of Life

“ISM supplied us with their industrial-scale ultrasonic processor, ISP-3000, which we have been using to make nutraceutical and cosmetic products, as well as for essential oil extraction and several similar applications for over a year. With this processor, the efficiency of plant oil extraction, emulsification and solids’ dispersion is superb, enabling us to make products comprising dozens of different oils, solid powders and water. The products seem to remain permanently stable and have many other enhanced properties: our customers consistently report superior taste, texture and overall performance.”
See more Customer Testimonials

Videos

  • ISM’s Barbell Horn Ultrasonic Technology Introduction and How We Scale Up
  • Translucent Nanoemulsion Produced with LSP-600 and BSP-1200 in the Batch Mode
  • Making a Translucent Nanoemulsion with ISP-3000 in the Flow-Through Mode
Watch All videos

Ebooks

  • MAKING STABLE EMULSIONS: A Guide to Formulation and Processing Conditions Optimization
    Download PDF

Presentations

  • High-Intensity Ultrasonic Liquid Processing
    Download PDF
  • Drug Nano-Milling by Scalable High-Amplitude Ultrasound
    Download PDF
  • Continuous Industrial-Scale Processing of Liquids by High-Amplitude Ultrasound
    Download PDF
  • Manufacture of Nanoemulsions: The Scale-up Perspective
    Download PDF
  • Cell Disruption by High-Intensity Ultrasound
    Download PDF

Have Questions?

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or request a quotation.

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