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Home » Pharmaceutical

Pharmaceutical

ultrasonic processing for pharmaceutical applications - nanoemulsions, liposomes, nanocrystallization
  • Manufacture uniform nanocrystals, nanoemulsions, and liposomes on laboratory, bench and industrial scales.
  • Greatly increase the bioavailability and accelerate the onset of action of hydrophobic bioactive compounds.
  • Extract active pharmaceutical ingredients from biomass by efficient cell disruption (lysis).

Overview

Up to 40% of currently available bioactive substances and up to 70% of those under investigation by the pharmaceutical industry exhibit poor water solubility, resulting in low bioavailability and a delayed onset of action. Drug delivery platforms based on nanocarriers, such as nanocrystals, nanoemulsions, and liposomes, are very effective at overcoming these limitations. Industrial Sonomechanics® laboratory, bench, and industrial ultrasonic liquid processors provide a simple and effective means of producing uniform nanoparticles by exposing materials to high-intensity ultrasonic cavitation and the extremely strong shear forces it generates. These forces are also essential to the process of cell disruption (lysis), which is an important step in the extraction of pharmaceutical agents (e.g., recombinant proteins, medicinal oils, other bioactive substances) from yeast, bacterial and plant cells.

With Industrial Sonomechanics® patented Barbell Horn® Ultrasonic Technology (BHUT), these processes can be easily implemented at any scale of operation, guaranteeing reproducible and predictable high-quality results.
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Case Studies & Application Reports

Ultrasonic Disruption of Yeast Cells
CASE STUDY
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Scaling Up the Production of a Nanoemulsion with BHUT
CASE STUDY
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Ultrasonic Nanocrystallization of Nifedipine
CASE STUDY
Download PDF Ultrasonic nanocrystallization of nifedipine
Drug Carrier Liposomes and Nanoemulsions
APPLICATION REPORT
Download PDF
View all case studies

Blog Posts

Industrial Sonomechanics at CAMX 2026.
10/12/26

The Composites and Advanced Materials Expo (CAMX) 2026 Recap

Industrial Sonomechanics at CAMX 2026.

Industrial Sonomechanics (ISM) was pleased to exhibit at The Composites and Advanced Mat...

Read more...
BSP-1200 bench-scale processor showing the water-cooled ultrasonic stack, cooling lines, Barbell Horn, and process hardware.
09/29/26

Water-Cooled Piezoelectric Ultrasonic Transducers for Continuous Industrial Processing

BSP-1200 bench-scale processor showing the water-cooled ultrasonic stack, cooling lines, Barbell Horn, and process hardware.

At industrial power levels, an ultrasonic transducer must manage the heat generated in i...

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4th International Process Intensification Conference (IPIC4) 2026 Recap: Ultrasonic Nanoemulsion Manufacturing
09/10/26

4th International Process Intensification Conference (IPIC4) 2026 Recap: Ultrasonic Nanoemulsion Manufacturing

4th International Process Intensification Conference (IPIC4) 2026 Recap: Ultrasonic Nanoemulsion Manufacturing

Industrial Sonomechanics (ISM) was honored to participate in the 4th International Pro...

Read more...
Read all Blog Posts

Customer Testimonials

Dominic Notter, Matrix of Life

“ISM supplied us with their industrial-scale ultrasonic processor, ISP-3000, which we have been using to make nutraceutical and cosmetic products, as well as for essential oil extraction and several similar applications for over a year. With this processor, the efficiency of plant oil extraction, emulsification and solids’ dispersion is superb, enabling us to make products comprising dozens of different oils, solid powders and water. The products seem to remain permanently stable and have many other enhanced properties: our customers consistently report superior taste, texture and overall performance.”
See more Customer Testimonials

Videos

  • ISM’s Barbell Horn Ultrasonic Technology Introduction and How We Scale Up
  • Translucent Nanoemulsion Produced with LSP-600 and BSP-1200 in the Batch Mode
  • Making a Translucent Nanoemulsion with ISP-3000 in the Flow-Through Mode
Watch All videos

Ebooks

  • MAKING STABLE EMULSIONS: A Guide to Formulation and Processing Conditions Optimization
    Download PDF

Presentations

  • Drug Nano-Milling by Scalable High-Amplitude Ultrasound
    Download PDF

Presentations

  • High-Intensity Ultrasonic Liquid Processing
    Download PDF

Presentations

  • High-Intensity Ultrasonic Liquid Processing
    Download PDF
  • Drug Nano-Milling by Scalable High-Amplitude Ultrasound
    Download PDF
  • Continuous Industrial-Scale Processing of Liquids by High-Amplitude Ultrasound
    Download PDF
  • Manufacture of Nanoemulsions: The Scale-up Perspective
    Download PDF
  • Cell Disruption by High-Intensity Ultrasound
    Download PDF

Have Questions?

Consult with an application specialist
or request a quotation.

Contact Us

Frequently Asked Questions

What is ultrasonic processing used for in pharmaceutical manufacturing?

Ultrasonic processing produces uniform nanocarriers such as nanocrystals, nanoemulsions, and liposomes, and performs cell disruption (lysis) to extract active ingredients from biomass. These steps help overcome the poor water solubility that limits many drug compounds.

How does nanotechnology improve poorly soluble drugs?

Up to 40% of available bioactive substances, and up to 70% of those in development, have poor water solubility, which lowers bioavailability and delays onset. Formulating them as nanocrystals, nanoemulsions, or liposomes increases dissolution and absorption, improving therapeutic performance.

What is liposome drug production with ultrasound?

Liposomes are lipid vesicles that encapsulate active ingredients for targeted delivery. High-intensity ultrasonic cavitation reduces and homogenises lipid structures into uniform liposomes, providing a simple, reproducible production method on lab, bench, and industrial scales.

Can ultrasonic systems be used for cell disruption and extraction?

Yes. The strong shear forces generated by ultrasonic cavitation rupture yeast, bacterial, and plant cell walls, releasing recombinant proteins, medicinal oils, and other bioactive substances for downstream processing.

How is consistency maintained when scaling up?

Industrial Sonomechanics processors use patented Barbell Horn Ultrasonic Technology (BHUT), which preserves the required amplitude as equipment size increases, so processes validated in the lab transfer to production with reproducible, high-quality results.

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